As of December 19, 2021, there have been 921 guest stars on the show, with this figure rising to 925 if The Simpsons Movie is included. The show was awarded the Guinness World Record for 'Most Guest Stars Featured in a TV Series' in 2010. Grammer, Mason and three-time guest star Anne Hathaway all won the Primetime Emmy Award for Outstanding Voice-Over Performance for guest voice roles on the show.

Three guest stars, Ricky Gervais, Seth Rogen and Pete Holmes, earned writing credits for the episodes in which they appeared. Simmons, Sally Stevens, George Takei and Michael York have made over five appearances. Greene, Valerie Harper, Jan Hooks, Jane Kaczmarek, Stacy Keach, Kipp Lennon, J. Mantegna has appeared over thirty times, Grammer, Maurice LaMarche, Jon Lovitz and Frank Welker have appeared twenty times or more Glenn Close, Dawnn Lewis and Jackie Mason have appeared over ten times, while Albert Brooks, Michael Dees, Dana Gould, Terry W. After Wallace, Hartman made the most appearances, guest starring 52 times. Several guest stars have featured as recurring characters on the show, including Phil Hartman, Joe Mantegna and Kelsey Grammer. Singer Tony Bennett was the first guest star to appear as himself, appearing briefly in the season two episode ' Dancin' Homer'. The first credited guest star was Marcia Wallace who appeared in ' Bart the Genius' in her first stint as Bart's teacher Edna Krabappel. In the show's early years most guest stars voiced original characters, but as the show has continued the number of those appearing as themselves has increased. Guest voices have come from a wide range of professions, including actors, athletes, authors, musicians, artists, politicians and scientists. A feature film adaptation of the series called The Simpsons Movie, was released in 2007.

The series' 33rd season debuted on September 26, 2021, and 716 episodes of The Simpsons have aired. The shorts were developed into a half-hour prime time series which began in December 1989. The family was initially conceived by Groening for a series of animated shorts, which originally aired as a part of The Tracey Ullman Show between 19. The Simpsons focuses on the eponymous family, which consists of Homer, Marge, Bart, Lisa and Maggie. In addition to the show's regular cast of voice actors, celebrity guest stars have been a staple of The Simpsons, an American animated television sitcom created by Matt Groening for the Fox Broadcasting Company, since its first season. Actor Phil Hartman, who died in 1998, was the most recurring male guest actor on the show, appearing 52 times.

The simpsons season 30 guest stars